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Book The Protein Folding Problem and Tertiary Structure Prediction


The Protein Folding Problem and Tertiary Structure Prediction

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    Available in PDF - DJVU Format | The Protein Folding Problem and Tertiary Structure Prediction.pdf | Language: ENGLISH
    Kenneth M.Jr. Merz(Author)

    Book details

A solution to the protein folding problem has eluded researchers for more than 30 years. The stakes are high. Such a solution will make 40,000 more tertiary structures available for immediate study by translating theDNA sequence information in the sequence databases into three-dimensional protein structures. This translation will be indispensable for the analy­ sis of results from the Human Genome Project, de novo protein design, and manyother areas of biotechnological research. Finally, an in-depth study of the rules of protein folding should provide vital clues to the protein fold­ ing process. The search for these rules is therefore an important objectivefor theoretical molecular biology. Both experimental and theoretical ap­ proaches have been used in the search for a solution, with many promising results but no general solution. In recent years, there has been an exponen­tial increase in the power of computers. This has triggered an incredible outburst of theoretical approaches to solving the protein folding problem ranging from molecular dynamics-based studies of proteins in solution to theactual prediction of protein structures from first principles. This volume attempts to present a concise overview of these advances. Adrian Roitberg and Ron Elber describe the locally enhanced sam­ pling/simulated annealingconformational search algorithm (Chapter 1), which is potentially useful for the rapid conformational search of larger molecular systems.
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Book details

  • PDF | 596 pages
  • Kenneth M.Jr. Merz(Author)
  • Springer; Softcover reprint of the original 1st ed. 1994 edition (4 Oct. 2013)
  • English
  • 10
  • Health, Family & Lifestyle

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